Tranxene (clorazepate dipotassium) 10 mg
Brand name: Tranxene 10 mg by Sanofi
Treatment: Short term relief from Anxiety, acute alcohol withdrawal, management of partial seizures
Quantity per pack: 30 x 10 mg tablets
Price per pill: £1.20
Active Ingredient: Clorazepate Dipotassium
Tranxene (clorazepate dipotassium) 10 mg is indicated for the management of anxiety disorders. It is also indicated for the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not need treatment with an anxiolytic. It is also indicated as adjunctive therapy in the management of partial seizures.
Chemically, Tranxene is a benzodiazepine.
Long term use
The effectiveness of Tranxene (clorazepate dipotassium) 10 mg in long-term management of anxiety, that is, over 4 months, hasn’t been assessed by systematic clinical studies. Long-term studies in epileptic patients, however, have shown continued therapeutic activity. A physician should do regular assessments to determine the usefulness of the drug for the individual patient.
This medicine is also indicated for the symptomatic relief of acute alcohol withdrawal
Dosage and administration
For the symptomatic relief of anxiety
Tranxene (clorazepate dipotassium) 10 mg are administered orally in divided doses. The usual daily dose is 30 mg. Dosage should be adjusted gradually within the range of 15 to 60 mg daily in accordance with the response of the patient. In elderly or debilitated patients it is advisable to initiate treatment at a daily dose of 7.5 to 15 mg.
Tranxene tablets can also be taken in a single dose daily at bedtime. The recommended initial dose is 15 mg. After the initial dose, the response of the patient may require adjustment of subsequent dosage. Lower doses may be indicated in the elderly patient. Drowsiness may occur at the initiation of treatment and with dosage increment.
As an Adjunct to Antiepileptic Drugs
To minimize drowsiness, the recommended initial dosages and dosage increments should not be exceeded.
The maximum recommended initial dose in patients over 12 years old is 7.5 mg three times a day. Dosage should be increased by no more than 7.5 mg every week and should not exceed 90 mg/day.
Children (9-12 years)
The maximum recommended initial dose is 7.5 mg two times a day. Dosage should be increased by no more than 7.5 mg every week and should not exceed 60 mg/day.
The most common side effect reported was drowsiness. Less commonly reported (in descending order of occurrence) were:
- various gastrointestinal complaints
- blurred vision
- dry mouth
- mental confusion.
Other side effects included:
- transient skin rashes
- genitourinary complaints
- slurred speech.
There have been reports of abnormal liver and kidney function tests and of a decrease in haematocrit.
Decreases in systolic blood pressure has also been observed.