Atizolm 1 mg Etizolam
Brand name: Atizolm 1 mg Etizolam by Signature Pharmaceuticals Ltd
Treatment: Short term Anxiety and Insomnia, panic attacks, muscle relaxant, amnesia, convulsion
Quantity per pack: 30 x 1 mg tablets
Price per pill: £1.40
Active Ingredient: Etizolam
Atizolm 1 mg Etizolam is manufactured by Signature Pharmaceuticals. It is a medication that is prescribed to treat short term anxiety and insomnia. It reduces excessive or abnormal nerve cell activity and also has a calming effect on the brain. Etizolam can be suitable for the short term for treating insomnia. It can also be used short term for treating panic attacks and anxiety. If a benzodiazepine was recommended for the patient.
Etizolam has both sedative and muscle relaxing properties. These can assist in the treatment of, or relief from amnesia, anxiety and convulsion. Approval for medical use was given in 1983. After a successful patent application 11 years previous in 1972. Etizolam is FDA approved.
Directions for use
Atizolm 1 mg Etizolam tablets can be taken with or without food. Swallow the tablet whole without breaking, chewing or crushing it. Take with a glass of water and wash it down. Taking with meals can help you to remember to take the drug. Doing this will help you to maintain a consistent level of the medication in your body.
This medication is to only be taken in the dosage and for the duration prescribed by a doctor or your GP. Note: you should always consult with a doctor or your GP if you’re considering stopping the course before its completed. Early stoppage during a prescribed course could cause nausea and anxiety. Any prolonged use of this medicine should also be accompanied by regular monitoring of blood and liver functions.
The following side effects have been known, but not all are common when taking a course of Atizolm 1 mg Etizolam:
- Muscle coordination impaired
- Slurred speech
- Weakness in muscles
- Altered libido
- Visual disturbance
If Atizolm 1 mg Etizolam has prolonged periods of usage it can lead to blepharospasms. Very rarely, use of this drug can result in erythema annulare centrifugum skin lesions.
Do not take Atizolm 1 mg Etizolam tablets while drinking alcohol. Also out of the question is driving or operating any kind of machinery. During pregnancy or lactation, or by people suffering from impaired liver or kidney problems, consultation with a doctor should be sought.
Many Pharmaceutical companies have their own name branded versions of Etizolam. It is available under many different brand names, such as:
- Depas – a derivative of thienodiazepine, similar to benzodiazepine.
Etizolam molecules are different from benzodiazepine. This is due to the benzene ring being replaced with a ring fused from thiophene and triazole. This results in the Etizolam drug being classified as a thienotriazolodiazepine.
Etizolam Withdrawal, Tolerance and Dependence
As with benzodiazepines, sudden discontinuation or fast withdrawal from Etizolam can have the appearance of benzodiazepine withdrawal syndrome. Rebound insomnia is a common symptom. A particularly rare withdrawal symptom is Neuroleptic Malignant Syndrome. Which results show during a case of rapid discontinuation of Etizolam. This is relevant due to Etizolam’s relatively short half life in comparison to benzodiazepines like diazepam. Etizolam decreases in blood plasma levels less rapidly.
A comparison study in treating generalized anxiety disorder. The study involved comparing Alprazolam, Bromazepam and Etizolam. Tests revealed that all three of the drugs remained effective over 2 weeks. Etizolam, however, became more effective between weeks 2 and 4. By displaying a type of reverse-tolerance. Patients that received 0.5 mg of Etizolam twice a day over a 3 week period did not experience any cognitive deficits compared to those given a placebo.
On administering multiple doses of Etizolam or Lorazepam to rat neurons, it reveals that:
- Lorazepam resulted in a down-regulation of Aplha-1 (dependence/tolerance) binding sites.
- Etizolam resulted in an increase of Alpha-2 (reverse tolerance to anti-anxiety) binding sites.
- While there was observation of tolerance to anticonvulsant effects of Lorazepam, there was no observation of the same tolerance of Etizolam.
Etizolam absorbs relatively quickly and will reach peak plasma levels in between 30-120 minutes. So, its average half life is around 3 to 5 hours. It can be compared with other benzodiazepines that are short-acting. This is because it has powerful hypnotic properties. At the benzodiazepine receptor, Etizolam acts as an agonist producing both adverse and therapeutic effects.
Thienotriazolodiazepines is a new class of diazepines. It is easy to oxidize, quickly metabolize and has less of an accumulation risk. Even after prolonged use. Therefore, Etizolam’s anxiolytic action is around 6 times that of diazepam. Also, at higher doses, Etizolam reduces the time taken to fall asleep. Hence, it increases sleep time and reduces the number of awakenings.
Tests show that Etizolam did not affect deep sleep. Though it possibly reduces REM sleep. When assessed on healthy subjects undergoing ECG tests, it showed similar characteristics as those of tricyclic antidepressants.
There are other different strength dosage forms of Alprazolam on our website. Slightly higher is Etizest ER 1.5 Etizolam 1.5 mg manufactured by Consern Pharma. Then the next one up is Etivan-2 Etizolam JP 2 mg. And then the strongest version available is Etisafe-3 Etizolam 3 mg